Auflistung nach Autor "Begas, E."
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Caffeine metabolism in liver cirrhosis
Begas, E.; Asprodini, E. K.; Papakosta, S.; Maglaras, L.; Benakis, A.; Dalekos, G. (2005)Caffeine is metabolized primarily by CYP1A2. Several methods have been developed for the in vivo assessment of CYP1A2 activity using caffeine as a probe drug (2). These methods include the determination of caffeine clearance ... -
Development and validation of a reversed-phase HPLC method for CYP1A2 phenotyping by use of a caffeine metabolite ratio in saliva
Begas, E.; Kouvaras, E.; Tsakalof, A. K.; Bounitsi, M.; Asprodini, E. K. (2015)CYP1A2 is important for metabolizing various clinically used drugs. Phenotyping of CYP1A2 may prove helpful for drug individualization therapy. Several HPLC methods have been developed for quantification of caffeine ... -
In vivo evaluation of CUP1A2 and CYP2A6 activities in a Greek population during menopause
Begas, E.; Kouvaras, E.; Tsiokou, V.; Asprodini, E. K. (2008)Human CYP enzyme system is involved in the metabolism of various endogenous compounds. Previous studies have shown that CYP activity is influenced by age and gender. In the present study caffeine metabolites were used for ... -
In vivo evaluation of CYP1A2 CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios
Begas, E.; Kouvaras, E.; Tsakalof, A.; Papakosta, S.; Asprodini, E. K. (2007)A RP-HPLC method was developed for the assessment of caffeine and its metabolites in urine and was used for the evaluation of the CYP1A2, CYP2A6, xanthine oxidase (XO) and N-acetyl-transferase-2 (NAT-2) in vivo activities ... -
Simple and Reliable HPLC Method for the Monitoring of Methotrexate in Osteosarcoma Patients
Begas, E.; Papandreou, C.; Tsakalof, A.; Daliani, D.; Papatsibas, G.; Asprodini, E. (2014)Methotrexate (MTX) is a dihydrofolate reductase inhibitor that is used for the treatment of tumors and autoimmune diseases. Several automated binding assays are used in clinical practice and numerous chromatographic methods ...